Maltsev Dmitry Biography

Scientific biography of Maltsev Dmitry Valerievich, years of birth, Ukrainian. Born in the city of Lubny, Poltava region. He graduated with honors from the National Medical University named after A. Bogomoltz in the year in a specialty. In the years, he held an internship for neurology at the Department of Neurology and Reflex therapy of the National Academy of Postgraduate Education Nmapo nmapo nmapo nmapo with the year he worked as a neurologist in the Vishnevsky city hospital.

In parallel, he collaborated with the Department of Clinical Immunology and Allergology of the NMU named after A. Bogomolz, the head of Professor Drannik G. went to work at the Department of Clinical Immunology and Allergology of the NMU named after A. Bogomoletz, where he defended the dissertation for the scientific degree of candidate of medical sciences on the topic: “Immunity status of patients with a simple migraine and a simple migraine and a simple migraine and The role of herpesviruses in the pathogenesis of the disease.

" From the year he worked as deputy director of the neo -formed Institute of Immunology and Allergology at the NMU named after A. Bogomolts, director of the Institute Professor Kazmirchuk V. In the year, in connection with the reorganization, he was transferred to the position of head of the Laboratory of Immunology and Molecular Biology of the Naroded Institute of Experimental and Clinical Medicine of the NMU named after A.

Bogomoltsa of the Ministry of Health of Ukraine, where he still works. It specializes in the field of clinical immunology, neuroimmunology, opportunistic infections, immunotherapy, teachings on immunodeficiency human diseases. The author of 16 books on immunology and neuroimmunology, including 1 textbook for students of medical universities and 1 atlas on radiological manifestations of herpesviral infections.

The author of the article in the scientific periodicals of Ukraine and foreign countries, more performances at scientific conferences, about 30 patents and copyrights for inventions and useful models [1]. The author of a number of clinical studies on the improvement of approaches to the diagnosis and therapy of herpesvirus infections of a person. He proposed a modern clinical and radiological classification of herpesviral neuroinfections [2].

Successfully tested combined antiviral therapy for chronic reactivated infections caused by Epstein-Barr viruses [3] and type 6 herpes virus [4]. He described a number of original clinical cases in herpesvirus encephalitis [5, 6] and myelitis [7]. I improved modern ideas about the connection of reactivated herpesvirus infections with primary and secondary immunodeficiencies [8].

He developed, tested and proposed a number of new therapeutic strategies for the treatment of primary immunodeficiencies, including deficiency of myeloperoxidase phagocytes, mannoving lectin, class m immunoglobulin, elemental clouds of natural killers and natural killer T-lymphocytes. He described and described a new form of primary immunodeficiency - immunodeficiency associated with the genetic deficiency of the folate cycle.

He developed therapeutic approaches to compensate for the specified disease of the immune system. A number of works are devoted to the improvement of existing immunotherapeutic approaches. For the first time in the world, he showed that long-term immunotherapy gamma interferon leads to complete clinical and laboratory remission with a deficiency of myeloperoxidase phagocytes [9] these data were included in the national protocol for the deficiency of myeloproxidase.

Together with Tsarik, V. successfully tested the replacement immunotherapy with pentaglobin with the clinically manifesto electrical deficiency of class M Immunoglobulin [10]. He is the author of a number of scientific concepts. Studying the resistant cases of migraines without aura drew attention to the abnormally high load with lymphotropic herpesviruses in saliva in such patients.

As you know, the leading theory of migraine is trigemin-vascular, according to which an attack of pain is generated due to the excitation of the trigeminal nerve with secondary neurogenic inflammation in the brain shells and the wall of the vascular innervated by trigeminal nerve. Scientific works previously indicated the central mechanisms of the sensitization of trigeminal nerves in patients with migraine.

Maltsev D. Probation of antiviral treatment led to a decrease in the viral load in saliva, a decrease in signs of inflammation in the upper respiratory tract with a sharp reduction in the amount and severity of migraine attacks.

Based on these data, it proposed the concept of an immuno -dependent form of migraine with the peripheral mechanism of sensitization of trigeminal nerves due to the chronic inflammation of the upper respiratory tract associated with the abnormally active reproduction of lymphotropic herpesviruses [12]. Maltsev D, c. He showed that such patients have primary or secondary immunodeficiency, due to which it is not able to control herpesvirus infection.

He developed and improved approaches to serological diagnosis of herpesvirus neuroinfection by calculating the serum and cerebrospinal fluoride index of specific antibodies. He specified the semiotics of radical signs of herpesvirus infection in patients with temporal median epilepsy.He demonstrated that the serum concentration of the alpha tumor necrosis factor can be used as a biomarker of the severity of the condition and predicting the further course of the disease in patients with temporal median epilepsy associated with herpesviral infection [13].

He tested combined antiviral therapy, which ensured a decrease in the frequency and severity of epileptic seizures, as well as - improved sensitivity to anti -colsants [14]. Based on the data obtained, he proposed the concept of the virus-induced transformation of the synaptic transmission of excitation as a model of development of temporal median epilepsy with temporal median sclerosis induced by herpesviruses [15].

This concept involves a new philosophy in medicine with the ability to determine the etiological factor for allergies, autoimmune and oncology and, accordingly, conduct a personified etiotropic treatment aimed at compensating causal immunodeficiency. The author of the modern classification of primary minor immunodeficiency human diseases. Expanded the ideas about the clinical manifestations of these diseases.

He developed a number of new approaches to the treatment of primary minor immunodeficiency, which can improve control over infectious, allergic and autoimmune manifestations without changing doses of antimicrobial drugs, glucocorticosteroids and cytostostatics. He collected about the generalized scientific evidence in a special monograph on small immunodeficiency diseases [16].

He described a new form of primary immunodeficiency in patients with this genetic pathology and described the spectrum of clinical and laboratory manifestations of the disease [17]. He developed biomarkers to assess the severity of the state and predicting the disease. Improved the semiotics of radiological signs of encephalopathy in children with autism spectrum disorders associated with the genetic deficiency of the folate cycle.

He demonstrated the role of reactivated herpesvirus infections in the induction of demyelineization and antineuronal autoimmune in children with autism. He developed a stage approach to the treatment and rehabilitation of such patients that allows you to reduce the manifestations of a spectrum of autism or even get rid of those [19]. Together with Fedirko, V. described the spectrum of reactivated herpesvirus infections in severe atypical trigeminal neuralgia, improved approaches to the diagnosis of such infections.

He described the primary immunodeficiencies responsible for the loss of control over a reactivated virus in patients with trigeminal neuralgia. He showed that combined antiviral therapy aimed at eliminating reactivated herpesvirus infection and associated inflammation, helps to reduce the severity of pain in patients with atypical neuralgia of trigeminal nerve [20]. Literature 1.

Maltsev D. The Effectivence of Combined Antivical Therapy in Chronic Mononucleosis Caused by Epstein-Barr Virus June, Stockholm, Sweden 4. Kazmirchuk V.E., Maltsev D.